Dra. Mev Dominguez

Investigadora - Oslo Uni. Hospital, Noruega


Update on Hereditary Colorectal Cancer Genomics

 Mev Dominguez-Valentin

Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Norway

The last two decades have seen significant advancement in our understanding of colorectal tumors with DNA mismatch repair (MMR) deficiency. The up-coming knowledge from molecular and genetic alterations in various clinical conditions have refined the disease terminology and classification.

Hereditary non polyposis colorectal cancer (HNPCC) encompasses a spectrum of conditions that have significant phenotypic overlap, and making a genetic diagnosis in familial colorectal cancer cases can be clinically challenging.

Distinguishing among the HNPCC disorders is important clinically, as the approach to surveillance for patients and their at-risk family members differs according to risks for colonic and extracolonic cancers associated with each syndrome. Longitudinal and next generation studies will provide valuable clinical information regarding the natural history of disease which will help differentiate the Lynch syndrome mimics and guide diagnosis and management for the heterogeneous conditions currently grouped under the category of familial colorectal cancer.

 Sobre la Dra. Dominguez

Se graduó en la Facultad de Biología de la Universidad Nacional Mayor de San Marcos. Viajó a Brasil para realizar sus estudios de maestría en la Facultad de Medicina de Ribeirao Preto, Universidad de Sao Paulo, Brasil, especializándose en el estudio de las bases genéticas de los tumores cerebrales. Durante sus estudios de doctorado se centró en la expresión genética del cáncer colorrectal en el Hospital AC Camargo de la Universidad Estadual de Sao Paulo. Ha realizado estancias postdoctorales en el Centro Jean Perrin en Francia y en la Universidad de Lund en Suecia. Actualmente  es investigadora del Departamento de Biología Molecular de la Universidad de Oslo, Noruega.

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